fentanyl transdermal and pentobarbital each raise sedation. Steer clear of or Use Alternate Drug. Restrict use to sufferers for whom alternative remedy choices are insufficient
pentobarbital decreases amounts of panobinostat by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Powerful CYP3A4 inducers can reduce panobinostat stages by ~70% and bring about cure failure.
pentobarbital will decrease the level or result of conivaptan by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.
pentobarbital will decrease the extent or effect of estrogens esterified by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.
pentobarbital will lower the level or result of mavacamten by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.
[two] Research have shown the superiority of pentobarbital because of its more rapidly brain penetration and shorter 50 %-daily life, thereby making it the popular therapy for refractory position epilepticus.
As medical data regarding the usage of pentobarbital for click here the duration of breastfeeding are missing, it can be advisable to think about choice brokers, especially when nursing a newborn or preterm infant.[17]
pentobarbital increases consequences of ifosfamide by affecting hepatic enzyme CYP2B6 metabolism. Use Caution/Monitor. Coadministration of ifosfamide with CYP2B6 inducers could improve metabolism of ifosfamide to its metabolite. Watch for improved results/toxicities if coupled with CYP2B6 inducers.
pentobarbital will minimize the level or effect of carbamazepine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.
pentobarbital will reduce the extent or impact of cobimetinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Steer clear of coadministration. Sturdy or reasonable CYP3A inducers could minimize cobimetinib systemic exposure by >eighty% and decrease its efficacy.
pentobarbital will reduce the level or effect of saxagliptin by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Importance Mysterious.
pentobarbital raises toxicity of methoxyflurane by rising metabolism. Contraindicated. Greater metabolism of methoxyflurane to nephrotoxic compounds.
pentobarbital will lessen the extent or impact of estradiol vaginal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.
pentobarbital will lessen the level or effect of dutasteride by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Significance Not known.